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KMID : 0624620080410060444
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BMB Reports
2008 Volume.41 No. 6 p.444 ~ p.447
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Modeled structure of trypanothione reductase of Leishmania infantum
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Singh Bishal K.
Sarkar Nandini
Jagannadham M.V.
Dubey Vikash K.
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Abstract
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Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity. [BMB reports 2008; 41(6): 444-447]
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KEYWORD
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Drug design, Structure-Function, Reductase activity, Homology Modeling
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